DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome

Inhibiting the histone 3 lysine 79 (H3K79) methyltransferase, disruptor of telomeric silencing 1-like (DOT1L), increases the efficiency of reprogramming somatic cells to induced pluripotent stem cells (iPSCs). Here, we find that, despite the enrichment of H3K79 methylation on thousands of actively t...

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Detalles Bibliográficos
Autores principales: Wille, Coral K., Sridharan, Rupa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828533/
https://www.ncbi.nlm.nih.gov/pubmed/34995500
http://dx.doi.org/10.1016/j.stemcr.2021.12.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828533/
https://www.ncbi.nlm.nih.gov/pubmed/34995500
http://dx.doi.org/10.1016/j.stemcr.2021.12.004

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