CRISPR activation enables high-fidelity reprogramming into human pluripotent stem cells

Conventional reprogramming methods rely on the ectopic expression of transcription factors to reprogram somatic cells into induced pluripotent stem cells (iPSCs). The forced expression of transcription factors may lead to off-target gene activation and heterogeneous reprogramming, resulting in the e...

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Detalles Bibliográficos
Autores principales: Sokka, Joonas, Yoshihara, Masahito, Kvist, Jouni, Laiho, Laura, Warren, Andrew, Stadelmann, Christian, Jouhilahti, Eeva-Mari, Kilpinen, Helena, Balboa, Diego, Katayama, Shintaro, Kyttälä, Aija, Kere, Juha, Otonkoski, Timo, Weltner, Jere, Trokovic, Ras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828555/
https://www.ncbi.nlm.nih.gov/pubmed/35063129
http://dx.doi.org/10.1016/j.stemcr.2021.12.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828555/
https://www.ncbi.nlm.nih.gov/pubmed/35063129
http://dx.doi.org/10.1016/j.stemcr.2021.12.017

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