Survey of tumorigenic sensitivity in 6-month rasH2-Tg mice studies compared with 2-year rodent assays

The pharmacokinetic endpoint of a 25-fold increase in human exposure is one of the specified criteria for high-dose selection for 2-year carcinogenicity studies in rodents according to ICH S1C(R2). However, this criterion is not universally accepted for 6-month carcinogenicity tests in rasH2-Tg mice...

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Detalles Bibliográficos
Autores principales: Hisada, Shigeru, Tsubota, Kenjiro, Inoue, Kenji, Yamada, Hisaharu, Ikeda, Takanori, Sistare, Frank D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828610/
https://www.ncbi.nlm.nih.gov/pubmed/35221496
http://dx.doi.org/10.1293/tox.2021-0031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828610/
https://www.ncbi.nlm.nih.gov/pubmed/35221496
http://dx.doi.org/10.1293/tox.2021-0031

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