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Survey of tumorigenic sensitivity in 6-month rasH2-Tg mice studies compared with 2-year rodent assays
The pharmacokinetic endpoint of a 25-fold increase in human exposure is one of the specified criteria for high-dose selection for 2-year carcinogenicity studies in rodents according to ICH S1C(R2). However, this criterion is not universally accepted for 6-month carcinogenicity tests in rasH2-Tg mice...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Japanese Society of Toxicologic Pathology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828610/ https://www.ncbi.nlm.nih.gov/pubmed/35221496 http://dx.doi.org/10.1293/tox.2021-0031 |