Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors

Inhibition of PIKfyve phosphoinositide kinase selectively kills autophagy-dependent cancer cells by disrupting lysosome homeostasis. Here, we show that PIKfyve inhibitors can also selectively eliminate pluripotent embryonal carcinoma cells (ECCs), embryonic stem cells, and induced pluripotent stem c...

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Detalles Bibliográficos
Autores principales: Chakraborty, Arup R., Vassilev, Alex, Jaiswal, Sushil K., O'Connell, Constandina E., Ahrens, John F., Mallon, Barbara S., Pera, Martin F., DePamphilis, Melvin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828683/
https://www.ncbi.nlm.nih.gov/pubmed/35063131
http://dx.doi.org/10.1016/j.stemcr.2021.12.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828683/
https://www.ncbi.nlm.nih.gov/pubmed/35063131
http://dx.doi.org/10.1016/j.stemcr.2021.12.013

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