Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

The transcription factor RUNX1 is a critical regulator of developmental hematopoiesis and is frequently disrupted in leukemia. Runx1 is a large, complex gene that is expressed from two alternative promoters under the spatiotemporal control of multiple hematopoietic enhancers. To dissect the dynamic...

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Detalles Bibliográficos
Autores principales: Owens, Dominic D. G., Anselmi, Giorgio, Oudelaar, A. Marieke, Downes, Damien J., Cavallo, Alessandro, Harman, Joe R., Schwessinger, Ron, Bucakci, Akin, Greder, Lucas, de Ornellas, Sara, Jeziorska, Danuta, Telenius, Jelena, Hughes, Jim R., de Bruijn, Marella F. T. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828719/
https://www.ncbi.nlm.nih.gov/pubmed/35140205
http://dx.doi.org/10.1038/s41467-022-28376-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828719/
https://www.ncbi.nlm.nih.gov/pubmed/35140205
http://dx.doi.org/10.1038/s41467-022-28376-8

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