Antiproliferative effects of AAV-delivered CRISPR/Cas9-based degradation of the HPV18-E6 gene in HeLa cells

Human papillomavirus infections are associated with most cervical cancers, which are the fourth most common cancer in women. HPV-E6 protein binds to protein p53 and inhibits its function, leading to the switching of normal cells toward cancer cells. Here, we disrupted the HPV-E6 gene and investigate...

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Detalles Bibliográficos
Autores principales: Noroozi, Zahra, Shamsara, Mehdi, Valipour, Elahe, Esfandyari, Sahar, Ehghaghi, Alireza, Monfaredan, Amir, Azizi, Zahra, Motevaseli, Elahe, Modarressi, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828776/
https://www.ncbi.nlm.nih.gov/pubmed/35140292
http://dx.doi.org/10.1038/s41598-022-06025-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828776/
https://www.ncbi.nlm.nih.gov/pubmed/35140292
http://dx.doi.org/10.1038/s41598-022-06025-w

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