Cargando…

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

DNA methylation microarrays can be employed to interrogate cell-type composition in complex tissues. Here, we expand reference-based deconvolution of blood DNA methylation to include 12 leukocyte subtypes (neutrophils, eosinophils, basophils, monocytes, naïve and memory B cells, naïve and memory CD4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salas, Lucas A., Zhang, Ze, Koestler, Devin C., Butler, Rondi A., Hansen, Helen M., Molinaro, Annette M., Wiencke, John K., Kelsey, Karl T., Christensen, Brock C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828780/ https://www.ncbi.nlm.nih.gov/pubmed/35140201 http://dx.doi.org/10.1038/s41467-021-27864-7

Ejemplares similares

Calculating detection limits and uncertainty of reference-based deconvolution of whole-blood DNA methylation data
por: Bell-Glenn, Shelby, et al.
Publicado: (2023)

Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation
por: Zhang, Ze, et al.
Publicado: (2023)

An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray
por: Salas, Lucas A., et al.
Publicado: (2018)

HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data
por: Zhang, Ze, et al.
Publicado: (2022)

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)
por: Koestler, Devin C., et al.
Publicado: (2016)

Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages
por: Zhang, Ze, et al.
Publicado: (2022)

A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources
por: Berglund-Brown, Isabella, et al.
Publicado: (2022)

Absence of an embryonic stem cell DNA methylation signature in human cancer
por: Zhang, Ze, et al.
Publicado: (2019)

Tracing human stem cell lineage during development using DNA methylation
por: Salas, Lucas A., et al.
Publicado: (2018)

Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative using DNA methylation-based methods
por: Nissen, Emily, et al.
Publicado: (2023)

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
por: Gervin, Kristina, et al.
Publicado: (2019)

Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes
por: Chen, Ji-Qing, et al.
Publicado: (2022)

Genome-Scale Methylation Analysis Identifies Immune Profiles and Age Acceleration Associations with Bladder Cancer Outcomes
por: Chen, Ji-Qing, et al.
Publicado: (2023)

Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker
por: Tang, Emily, et al.
Publicado: (2022)

DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival
por: Wiencke, J. K., et al.
Publicado: (2022)

A Novel Framework for the Identification of Reference DNA Methylation Libraries for Reference-Based Deconvolution of Cellular Mixtures
por: Bell-Glenn, Shelby, et al.
Publicado: (2022)

Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival
por: Wiencke, John K., et al.
Publicado: (2017)

DNA methylation arrays as surrogate measures of cell mixture distribution
por: Houseman, Eugene Andres, et al.
Publicado: (2012)

Down Syndrome Altered Cell Composition in Blood, Brain, and Buccal Swab Samples Profiled by DNA-Methylation-Based Cell-Type Deconvolution
por: Zhang, Ze, et al.
Publicado: (2023)

Cell-type deconvolution from DNA methylation: a review of recent applications
por: Titus, Alexander J., et al.
Publicado: (2017)

Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange
por: Kelsey, Karl T., et al.
Publicado: (2019)

CpG island methylation profile in non-invasive oral rinse samples is predictive of oral and pharyngeal carcinoma
por: Langevin, Scott M., et al.
Publicado: (2015)

Methylation-derived inflammatory measures and lung cancer risk and survival
por: Zhao, Naisi, et al.
Publicado: (2021)

Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes
por: Titus, Alexander J., et al.
Publicado: (2017)

Integrative epigenetic and genetic pan-cancer somatic alteration portraits
por: Salas, Lucas A., et al.
Publicado: (2017)

Reference-free deconvolution of DNA methylation data and mediation by cell composition effects
por: Houseman, E. Andres, et al.
Publicado: (2016)

Cell type deconvolution of methylated cell-free DNA at the resolution of individual reads
por: Keukeleire, Pia, et al.
Publicado: (2023)

Sparse deconvolution of high-density super-resolution images
por: Hugelier, Siewert, et al.
Publicado: (2016)

Dense deconvolution net: Multi path fusion and dense deconvolution for high resolution skin lesion segmentation
por: He, Xinzi, et al.
Publicado: (2018)

DNA methylation in the adipose tissue and whole blood of Agent Orange-exposed Operation Ranch Hand veterans: a pilot study
por: Rytel, Matthew R., et al.
Publicado: (2021)

Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma
por: Wilkins, Owen M, et al.
Publicado: (2017)

DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer
por: Johnson, Kevin C., et al.
Publicado: (2015)

Corrigendum: Sparse deconvolution of high-density super-resolution images
por: Hugelier, Siewert, et al.
Publicado: (2016)

HiTAIC: hierarchical tumor artificial intelligence classifier traces tissue of origin and tumor type in primary and metastasized tumors using DNA methylation
por: Zhang, Ze, et al.
Publicado: (2023)

Erratum to: Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, et al. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 2011; 6
por: Langevin, Scott M., et al.
Publicado: (2012)

Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes
por: Maccani, Jennifer Z.J., et al.
Publicado: (2015)

Altered immune phenotype and DNA methylation in panic disorder
por: Petersen, Curtis L., et al.
Publicado: (2020)

Identification of Methylated Genes Associated with Aggressive Bladder Cancer
por: Marsit, Carmen J., et al.
Publicado: (2010)

An Optimal Subspace Deconvolution Algorithm for Robust and High-Resolution Beamforming
por: Su, Xiruo, et al.
Publicado: (2022)

Spatial transcriptomics deconvolution at single-cell resolution using Redeconve
por: Zhou, Zixiang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vu13rhej7p2h76u4mpknua642a