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Molecular and in vivo phenotyping of missense variants of the human glucagon receptor

Naturally occurring missense variants of G protein–coupled receptors with loss of function have been linked to metabolic disease in case studies and in animal experiments. The glucagon receptor, one such G protein–coupled receptor, is involved in maintaining blood glucose and amino acid homeostasis;...

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Detalles Bibliográficos
Autores principales: van der Velden, Wijnand J.C., Lindquist, Peter, Madsen, Jakob S., Stassen, Roderick H.M.J., Wewer Albrechtsen, Nicolai J., Holst, Jens J., Hauser, Alexander S., Rosenkilde, Mette M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829087/
https://www.ncbi.nlm.nih.gov/pubmed/34801547
http://dx.doi.org/10.1016/j.jbc.2021.101413