Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway regulates intestinal mucosal barrier in Crohn's disease

BACKGROUND: Intestinal barrier impairment plays an essential role in the pathogenesis of Crohn's disease (CD), and claudins (CLDNs) dysfunction contributes to intestinal mucosa injury. SOX9, an important transcription factor, is upregulated in the disease-affected colon of patients with CD; how...

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Detalles Bibliográficos
Autores principales: Zhuang, Xiaojun, Chen, Baili, Huang, Shanshan, Han, Jing, Zhou, Gaoshi, Xu, Shu, Chen, Minhu, Zeng, Zhirong, Zhang, Shenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829091/
https://www.ncbi.nlm.nih.gov/pubmed/35124427
http://dx.doi.org/10.1016/j.ebiom.2022.103846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829091/
https://www.ncbi.nlm.nih.gov/pubmed/35124427
http://dx.doi.org/10.1016/j.ebiom.2022.103846

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