Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection

Hepatic gene therapy by delivering non-integrating therapeutic vectors in newborns remains challenging due to the risk of dilution and loss of efficacy in the growing liver. Previously we reported on hepatocyte transfection in piglets by intraportal injection of naked DNA vectors. Here, we establish...

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Detalles Bibliográficos
Autores principales: Chan, Tatjana, Grisch-Chan, Hiu Man, Schmierer, Philipp, Subotic, Ulrike, Rimann, Nicole, Scherer, Tanja, Hetzel, Udo, Bozza, Matthias, Harbottle, Richard, Williams, James A., Steblaj, Barbara, Ringer, Simone K., Häberle, Johannes, Sidler, Xaver, Thöny, Beat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829443/
https://www.ncbi.nlm.nih.gov/pubmed/35211639
http://dx.doi.org/10.1016/j.omtm.2022.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829443/
https://www.ncbi.nlm.nih.gov/pubmed/35211639
http://dx.doi.org/10.1016/j.omtm.2022.01.006

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