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Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection
Hepatic gene therapy by delivering non-integrating therapeutic vectors in newborns remains challenging due to the risk of dilution and loss of efficacy in the growing liver. Previously we reported on hepatocyte transfection in piglets by intraportal injection of naked DNA vectors. Here, we establish...
Autores principales: | Chan, Tatjana, Grisch-Chan, Hiu Man, Schmierer, Philipp, Subotic, Ulrike, Rimann, Nicole, Scherer, Tanja, Hetzel, Udo, Bozza, Matthias, Harbottle, Richard, Williams, James A., Steblaj, Barbara, Ringer, Simone K., Häberle, Johannes, Sidler, Xaver, Thöny, Beat |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829443/ https://www.ncbi.nlm.nih.gov/pubmed/35211639 http://dx.doi.org/10.1016/j.omtm.2022.01.006 |
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