Preventing packaging of translatable P5-associated DNA contaminants in recombinant AAV vector preps

Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer plasmids can be packaged into rAAV alongside the intended expression casset...

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Detalles Bibliográficos
Autores principales: Brimble, Mark A., Cheng, Pei-Hsin, Winston, Stephen M., Reeves, Isaiah L., Souquette, Aisha, Spence, Yunyu, Zhou, Junfang, Wang, Yong-Dong, Morton, Christopher L., Valentine, Marcus, Thomas, Paul G., Nathwani, Amit C., Gray, John T., Davidoff, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829444/
https://www.ncbi.nlm.nih.gov/pubmed/35211640
http://dx.doi.org/10.1016/j.omtm.2022.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829444/
https://www.ncbi.nlm.nih.gov/pubmed/35211640
http://dx.doi.org/10.1016/j.omtm.2022.01.008

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