Changes in CYP3A4 Enzyme Expression and Biochemical Markers Under Acute Hypoxia Affect the Pharmacokinetics of Sildenafil

To investigate the effects of pathological, physiological, biochemical and metabolic enzymes CYP3A4 on the pharmacokinetics of sildenafil under acute hypoxia, rats were randomly divided into the plain group (50 m above sea level), acute plateau group 1 (2300 m above sea level), and acute plateau gro...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Juanhong, Wang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829446/
https://www.ncbi.nlm.nih.gov/pubmed/35153825
http://dx.doi.org/10.3389/fphys.2022.755769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829446/
https://www.ncbi.nlm.nih.gov/pubmed/35153825
http://dx.doi.org/10.3389/fphys.2022.755769

Ejemplares similares