Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to Plasmodium yoelii, Limits Malaria-Associated Disruption of Intestinal Barrier Integrity and Reduces Parasite Transmission to Anopheles stephensi

An increase in mast cells (MCs) and MCs mediators has been observed in malaria-associated bacteremia, however, the role of these granulocytes in malarial immunity is poorly understood. Herein, we studied the role of mouse MC protease (Mcpt) 4, an ortholog of human MC chymase, in malaria-induced bact...

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Detalles Bibliográficos
Autores principales: Céspedes, Nora, Donnelly, Erinn L., Lowder, Casey, Hansten, Gretchen, Wagers, Delaney, Briggs, Anna M., Schauer, Joseph, Haapanen, Lori, Åbrink, Magnus, Van de Water, Judy, Luckhart, Shirley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829543/
https://www.ncbi.nlm.nih.gov/pubmed/35154114
http://dx.doi.org/10.3389/fimmu.2022.801120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829543/
https://www.ncbi.nlm.nih.gov/pubmed/35154114
http://dx.doi.org/10.3389/fimmu.2022.801120

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