Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines

[Image: see text] 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp(3) (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qiang, Yao, Xia, Xu, Xian-jing, Zhang, Shuai, Ren, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829863/
https://www.ncbi.nlm.nih.gov/pubmed/35155923
http://dx.doi.org/10.1021/acsomega.1c06029
Descripción
Sumario:[Image: see text] 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp(3) (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.

Ejemplares similares