Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines

[Image: see text] 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp(3) (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a...

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Autores principales: Wang, Qiang, Yao, Xia, Xu, Xian-jing, Zhang, Shuai, Ren, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829863/
https://www.ncbi.nlm.nih.gov/pubmed/35155923
http://dx.doi.org/10.1021/acsomega.1c06029
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author Wang, Qiang
Yao, Xia
Xu, Xian-jing
Zhang, Shuai
Ren, Lei
author_facet Wang, Qiang
Yao, Xia
Xu, Xian-jing
Zhang, Shuai
Ren, Lei
author_sort Wang, Qiang
collection PubMed
description [Image: see text] 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp(3) (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.
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spelling pubmed-88298632022-02-11 Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines Wang, Qiang Yao, Xia Xu, Xian-jing Zhang, Shuai Ren, Lei ACS Omega [Image: see text] 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp(3) (C–H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator. American Chemical Society 2022-01-27 /pmc/articles/PMC8829863/ /pubmed/35155923 http://dx.doi.org/10.1021/acsomega.1c06029 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wang, Qiang
Yao, Xia
Xu, Xian-jing
Zhang, Shuai
Ren, Lei
Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
title Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
title_full Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
title_fullStr Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
title_full_unstemmed Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
title_short Electrochemical [4 + 1] Tandem sp(3)(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
title_sort electrochemical [4 + 1] tandem sp(3)(c–h) double amination for the direct synthesis of 3-acyl-functionalized imidazo[1,5-a]pyridines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829863/
https://www.ncbi.nlm.nih.gov/pubmed/35155923
http://dx.doi.org/10.1021/acsomega.1c06029
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