Dose-Dependent Bioavailability and Tissue Distribution of the ATR Inhibitor AZD6738 (ceralasertib) in Mice

PURPOSE: Ataxia telangiectasia and Rad3-related (ATR) initiates and regulates cellular responses to DNA damage, such as those caused by cancer treatments. Several ATR inhibitors (ATRi) are in clinical development including AZD6738. Therapeutic indices among ATRi may differ as a result of varying pot...

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Detalles Bibliográficos
Autores principales: Kiesel, Brian F., Guo, Jianxia, Parise, Robert. A, Venkataramanan, Raman, Clump, David A., Bakkenist, Christopher J., Beumer, Jan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829872/
https://www.ncbi.nlm.nih.gov/pubmed/35066692
http://dx.doi.org/10.1007/s00280-021-04388-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829872/
https://www.ncbi.nlm.nih.gov/pubmed/35066692
http://dx.doi.org/10.1007/s00280-021-04388-x

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