Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A

[Image: see text] The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn(2+) metallophore and inhibitor of metallo-β-lactamases (MBLs) which reverses β-lactam resistance. The first crystal structure of an AMA coordination complex is reported and reveals a pentadentate ligand with d...

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Detalles Bibliográficos
Autores principales: Koteva, Kalinka, Sychantha, David, Rotondo, Caitlyn M., Hobson, Christian, Britten, James F., Wright, Gerard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829947/
https://www.ncbi.nlm.nih.gov/pubmed/35155911
http://dx.doi.org/10.1021/acsomega.1c05757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829947/
https://www.ncbi.nlm.nih.gov/pubmed/35155911
http://dx.doi.org/10.1021/acsomega.1c05757

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