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Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A

[Image: see text] The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn(2+) metallophore and inhibitor of metallo-β-lactamases (MBLs) which reverses β-lactam resistance. The first crystal structure of an AMA coordination complex is reported and reveals a pentadentate ligand with d...

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Detalles Bibliográficos
Autores principales:	Koteva, Kalinka, Sychantha, David, Rotondo, Caitlyn M., Hobson, Christian, Britten, James F., Wright, Gerard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829947/ https://www.ncbi.nlm.nih.gov/pubmed/35155911 http://dx.doi.org/10.1021/acsomega.1c05757

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