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P53: Stability from the Ubiquitin–Proteasome System and Specific 26S Proteasome Inhibitors
[Image: see text] Protein p53 is degraded by the 26S proteasome, a protein complex that breaks down cellular proteins. Degradation begins with activation of the protein ubiquitin (Ub) by the ubiquitin-activating E1 enzymes, ubiquitin-conjugating E2 enzymes, and ubiquitin E3 ligases, linking Ub or th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829948/ https://www.ncbi.nlm.nih.gov/pubmed/35155881 http://dx.doi.org/10.1021/acsomega.1c04726 |