P53: Stability from the Ubiquitin–Proteasome System and Specific 26S Proteasome Inhibitors

[Image: see text] Protein p53 is degraded by the 26S proteasome, a protein complex that breaks down cellular proteins. Degradation begins with activation of the protein ubiquitin (Ub) by the ubiquitin-activating E1 enzymes, ubiquitin-conjugating E2 enzymes, and ubiquitin E3 ligases, linking Ub or th...

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Detalles Bibliográficos
Autores principales: do Patrocinio, Andressa Barban, Rodrigues, Vanderlei, Guidi Magalhães, Lizandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829948/
https://www.ncbi.nlm.nih.gov/pubmed/35155881
http://dx.doi.org/10.1021/acsomega.1c04726

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