Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness

BACKGROUND: Mitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each individual due to maternal germline inheritance, deleterious mutations and intact mtDNA molecules frequently co-exist (heteroplasmy). A number of factors, suc...

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Detalles Bibliográficos
Autores principales: Meshnik, Lana, Bar-Yaacov, Dan, Kasztan, Dana, Neiger, Tali, Cohen, Tal, Kishner, Mor, Valenci, Itay, Dadon, Sara, Klein, Christopher J., Vance, Jeffery M., Nevo, Yoram, Züchner, Stephan, Ovadia, Ofer, Mishmar, Dan, Ben-Zvi, Anat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829988/
https://www.ncbi.nlm.nih.gov/pubmed/35139855
http://dx.doi.org/10.1186/s12915-022-01241-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829988/
https://www.ncbi.nlm.nih.gov/pubmed/35139855
http://dx.doi.org/10.1186/s12915-022-01241-2

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