PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

BACKGROUND: The enzymatic conversion of arginine to citrulline is involved in gene and protein regulation and in alerting the immune system to stressed cells, including tumor cells. Nucleophosmin (NPM) is a nuclear protein that plays key roles in cellular metabolism including ribosome biogenesis, mR...

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Detalles Bibliográficos
Autores principales: Choudhury, Ruhul H, Symonds, Peter, Paston, Samantha J, Daniels, Ian, Cook, Katherine W, Gijon, Mohamed, Metheringham, Rachael L, Brentville, Victoria A, Durrant, Lindy G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830261/
https://www.ncbi.nlm.nih.gov/pubmed/35140112
http://dx.doi.org/10.1136/jitc-2021-003526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830261/
https://www.ncbi.nlm.nih.gov/pubmed/35140112
http://dx.doi.org/10.1136/jitc-2021-003526

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