The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer’s disease

Disruption of retromer-dependent endosomal trafficking is considered pathogenic in late-onset Alzheimer’s disease (AD). Here, to investigate this disruption in the intact brain, we turn to a genetic mouse model where the retromer core protein VPS35 is depleted in hippocampal neurons, and then we rep...

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Detalles Bibliográficos
Autores principales: Qureshi, Yasir H., Berman, Diego E., Marsh, Samuel E., Klein, Ronald L., Patel, Vivek M., Simoes, Sabrina, Kannan, Suvarnambiga, Petsko, Gregory A., Stevens, Beth, Small, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830374/
https://www.ncbi.nlm.nih.gov/pubmed/35045281
http://dx.doi.org/10.1016/j.celrep.2021.110262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830374/
https://www.ncbi.nlm.nih.gov/pubmed/35045281
http://dx.doi.org/10.1016/j.celrep.2021.110262

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