Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML

The histone demethylase LSD1 is over-expressed in hematological tumors and has emerged as a promising target for anticancer treatment, so that several LSD1 inhibitors are under development and testing, in preclinical and clinical settings. However, the complete understanding of their complex mechani...

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Detalles Bibliográficos
Autores principales: Nicosia, Luciano, Boffo, Francesca Ludovica, Ceccacci, Elena, Conforti, Fabio, Pallavicini, Isabella, Bedin, Fabio, Ravasio, Roberto, Massignani, Enrico, Somervaille, Tim C. P., Minucci, Saverio, Bonaldi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830420/
https://www.ncbi.nlm.nih.gov/pubmed/34862459
http://dx.doi.org/10.1038/s41388-021-02123-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830420/
https://www.ncbi.nlm.nih.gov/pubmed/34862459
http://dx.doi.org/10.1038/s41388-021-02123-7

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