Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S phase, for subsequent multisite phosphorylati...

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Detalles Bibliográficos
Autores principales: Philip, Jasmin, Örd, Mihkel, Silva, Andriele, Singh, Shaneen, Diffley, John FX, Remus, Dirk, Loog, Mart, Ikui, Amy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830886/
https://www.ncbi.nlm.nih.gov/pubmed/35142288
http://dx.doi.org/10.7554/eLife.74437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830886/
https://www.ncbi.nlm.nih.gov/pubmed/35142288
http://dx.doi.org/10.7554/eLife.74437

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