The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons

MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage to activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components of the MRN complex compromises cell life. Mutations in MRE11, RAD50, and NBS1 cause human genomic instability syndromes Ataxia-Telangiecta...

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Detalles Bibliográficos
Autores principales: Ding, Mingmei, Qing, Xiaobing, Zhang, Guangyu, Baade-Büttner, Carolin, Gruber, Ralph, Lu, Haizhen, Ferguson, David O., Geis, Christian, Wang, Zhao-Qi, Zhou, Zhong-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831373/
https://www.ncbi.nlm.nih.gov/pubmed/35153719
http://dx.doi.org/10.3389/fnagi.2021.786199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831373/
https://www.ncbi.nlm.nih.gov/pubmed/35153719
http://dx.doi.org/10.3389/fnagi.2021.786199

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