SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia

An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 as a dependency in this disease. We demonstrate that SLC5A3 i...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Yiliang, Huang, Yu-Han, Skopelitis, Damianos S., Iyer, Shruti V., Costa, Ana S.H., Yang, Zhaolin, Kramer, Melissa, Adelman, Emmalee R., Klingbeil, Olaf, Demerdash, Osama E., Polyanskaya, Sofya A., Chang, Kenneth, Goodwin, Sara, Hodges, Emily, McCombie, W. Richard, Figueroa, Maria E., Vakoc, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831445/
https://www.ncbi.nlm.nih.gov/pubmed/34531253
http://dx.doi.org/10.1158/2159-8290.CD-20-1849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831445/
https://www.ncbi.nlm.nih.gov/pubmed/34531253
http://dx.doi.org/10.1158/2159-8290.CD-20-1849

Ejemplares similares