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Engineering and exploiting synthetic allostery of NanoLuc luciferase
Allostery enables proteins to interconvert different biochemical signals and form complex metabolic and signaling networks. We hypothesize that circular permutation of proteins increases the probability of functional coupling of new N- and C- termini with the protein’s active center through increase...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831504/ https://www.ncbi.nlm.nih.gov/pubmed/35145068 http://dx.doi.org/10.1038/s41467-022-28425-2 |