Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

Type 2 diabetes is associated with insulin resistance, impaired pancreatic β-cell insulin secretion, and nonalcoholic fatty liver disease. Tissue-specific SWELL1 ablation impairs insulin signaling in adipose, skeletal muscle, and endothelium, and impairs β-cell insulin secretion and glycemic control...

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Detalles Bibliográficos
Autores principales: Gunasekar, Susheel K., Xie, Litao, Kumar, Ashutosh, Hong, Juan, Chheda, Pratik R., Kang, Chen, Kern, David M., My-Ta, Chau, Maurer, Joshua, Heebink, John, Gerber, Eva E., Grzesik, Wojciech J., Elliot-Hudson, Macaulay, Zhang, Yanhui, Key, Phillip, Kulkarni, Chaitanya A., Beals, Joseph W., Smith, Gordon I., Samuel, Isaac, Smith, Jessica K., Nau, Peter, Imai, Yumi, Sheldon, Ryan D., Taylor, Eric B., Lerner, Daniel J., Norris, Andrew W., Klein, Samuel, Brohawn, Stephen G., Kerns, Robert, Sah, Rajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831520/
https://www.ncbi.nlm.nih.gov/pubmed/35145074
http://dx.doi.org/10.1038/s41467-022-28435-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831520/
https://www.ncbi.nlm.nih.gov/pubmed/35145074
http://dx.doi.org/10.1038/s41467-022-28435-0

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