Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats

Mutations in the putative glutamatergic synapse scaffolding protein SAP97 are associated with the development of schizophrenia in humans. However, the role of SAP97 in synaptic regulation is unclear. Here we show that SAP97 is expressed in the dendrites of granule neurons in the dentate gyrus but no...

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Detalles Bibliográficos
Autores principales: Kay, Yuni, Tsan, Linda, Davis, Elizabeth A., Tian, Chen, Décarie-Spain, Léa, Sadybekov, Anastasiia, Pushkin, Anna N., Katritch, Vsevolod, Kanoski, Scott E., Herring, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831576/
https://www.ncbi.nlm.nih.gov/pubmed/35145085
http://dx.doi.org/10.1038/s41467-022-28430-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831576/
https://www.ncbi.nlm.nih.gov/pubmed/35145085
http://dx.doi.org/10.1038/s41467-022-28430-5

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