Cargando…

Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis

Copy number alterations (CNAs) are pivotal genetic events in triple-negative breast cancer (TNBC). Here, our integrated copy number and transcriptome analysis of 302 TNBC patients reveals that gene alpha-endosulfine (ENSA) exhibits recurrent amplification at the 1q21.3 region and is highly expressed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yi-Yu, Ge, Jing-Yu, Zhu, Si-Yuan, Shao, Zhi-Ming, Yu, Ke-Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831589/ https://www.ncbi.nlm.nih.gov/pubmed/35145111 http://dx.doi.org/10.1038/s41467-022-28452-z

Ejemplares similares

ENSA and ARPP19 differentially control cell cycle progression and development
por: Hached, Khaled, et al.
Publicado: (2019)

Ensa controls S-phase length by modulating Treslin levels
por: Charrasse, Sophie, et al.
Publicado: (2017)

Punctuated Copy Number Evolution and Clonal Stasis in Triple-Negative Breast Cancer
por: Gao, Ruli, et al.
Publicado: (2016)

Association of FOSL1 copy number alteration and triple negative breast tumors
por: Serino, Leandro Tamião Rodrigues, et al.
Publicado: (2019)

Comparing copy-number profiles under multi-copy amplifications and deletions
por: Cordonnier, Garance, et al.
Publicado: (2020)

Comprehensive identification and characterization of somatic copy number alterations in triple-negative breast cancer
por: Li, Zaibing, et al.
Publicado: (2019)

Genomic copy number alterations as biomarkers for triple negative pregnancy-associated breast cancer
por: Suelmann, B. B. M., et al.
Publicado: (2022)

Prognostic Effect of Microenvironment Phenotype in Triple-Negative Breast Cancer: Biomarker Analysis of a Prospective Trial
por: Zhu, Si-Yuan, et al.
Publicado: (2021)

Copy number variation in triple negative breast cancer samples associated with lymph node metastasis()()
por: Pariyar, Mamta, et al.
Publicado: (2021)

Impact of whole genome amplification on analysis of copy number variants
por: Pugh, T. J., et al.
Publicado: (2008)

Amplification ratio control system for copy number variation genotyping
por: Guthrie, Philip A. I., et al.
Publicado: (2011)

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit
por: Hégarat, Nadia, et al.
Publicado: (2014)

The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation
por: Cundell, Michael J., et al.
Publicado: (2013)

Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers
por: Gross, E, et al.
Publicado: (2013)

Importance of Copy Number Alterations of FGFR1 and C-MYC Genes in Triple Negative Breast Cancer
por: Nedeljković, Milica, et al.
Publicado: (2019)

Classification of human cancers based on DNA copy number amplification modeling
por: Myllykangas, Samuel, et al.
Publicado: (2008)

Correction: PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit
Publicado: (2014)

The MASTL-ENSA-PP2A/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma
por: Gouttia, Odjo G., et al.
Publicado: (2022)

Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer
por: Wu, Zhiyuan, et al.
Publicado: (2020)

Integrated copy number and miRNA expression analysis in triple negative breast cancer of Latin American patients
por: Sugita, Bruna M., et al.
Publicado: (2019)

Unproductive Effects of ALK Gene Amplification and Copy Number Gain in Non-Small-Cell Lung Cancer. ALK Gene Amplification and Copy Gain in NSCLC
por: Zito Marino, Federica, et al.
Publicado: (2020)

Overweight as a Prognostic Factor for Triple-Negative Breast Cancers in Chinese Women
por: Hao, Shuang, et al.
Publicado: (2015)

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
por: Todd, Robert T, et al.
Publicado: (2020)

Multiple Displacement Amplification as a Solution for Low Copy Number Plasmid Sequencing
por: Yao, Kuan, et al.
Publicado: (2021)

Homologous recombination deficiency and glycolysis‐related pathway in adjuvant chemotherapy for triple‐negative breast cancer: A genomic landscape and biomarker assessment of the PATTERN trial
por: Zhu, Si‐Yuan, et al.
Publicado: (2021)

New insights into the prognostic value of Ki-67 labeling index in patients with triple-negative breast cancer
por: Hao, Shuang, et al.
Publicado: (2016)

Progress in Methods for Copy Number Variation Profiling
por: Gordeeva, Veronika, et al.
Publicado: (2022)

Genome-wide copy number profiling to detect gene amplifications in neural progenitor cells
por: Fischer, U., et al.
Publicado: (2014)

Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification
por: Van Bockstal, Mieke R., et al.
Publicado: (2020)

Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients
por: Ma, Jing, et al.
Publicado: (2021)

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression
por: Gualtieri, Alberto, et al.
Publicado: (2013)

The advance of adjuvant treatment for triple-negative breast cancer
por: Ge, Jingyu, et al.
Publicado: (2022)

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis
por: Jamal, Muhammad, et al.
Publicado: (2023)

Spectrum of EGFR Gene Copy Number Changes and KRAS Gene Mutation Status in Korean Triple Negative Breast Cancer Patients
por: Kim, Yoonjung, et al.
Publicado: (2013)

Immune-Activated Regional Lymph Nodes Predict Favorable Survival in Early-Stage Triple-Negative Breast Cancer
por: Chen, Yi-Yu, et al.
Publicado: (2020)

DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
por: Conconi, Donatella, et al.
Publicado: (2012)

Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma
por: Muñoz-Hidalgo, Lisandra, et al.
Publicado: (2019)

Estimating copy number using next-generation sequencing to determine ERBB2 amplification status
por: Nakamura, Kohei, et al.
Publicado: (2021)

Correction: Spectrum of EGFR Gene Copy Number Changes and KRAS Gene Mutation Status in Korean Triple Negative Breast Cancer Patients
Publicado: (2014)

Gene Co-expression Network and Copy Number Variation Analyses Identify Transcription Factors Associated With Multiple Myeloma Progression
por: Yu, Christina Y., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4m58jkhn5cr3np5vme00mpnu0c