Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy

Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, the mechanisms underlying ER stress remain poorly understood, thus reducing the options for exploring new pharmacological therapies for patients w...

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Detalles Bibliográficos
Autores principales: Ye, Hui, Chen, Chaobo, Wu, Hanghang, Zheng, Kang, Martín-Adrados, Beatriz, Caparros, Esther, Francés, Rubén, Nelson, Leonard J., Gómez del Moral, Manuel, Asensio, Iris, Vaquero, Javier, Bañares, Rafael, Ávila, Matías A., Andrade, Raúl J., Isabel Lucena, M., Martínez-Chantar, Maria Luz, Reeves, Helen L., Masson, Steven, Blumberg, Richard S., Gracia-Sancho, Jordi, Nevzorova, Yulia A., Martínez-Naves, Eduardo, Cubero, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831621/
https://www.ncbi.nlm.nih.gov/pubmed/35145060
http://dx.doi.org/10.1038/s41419-022-04580-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831621/
https://www.ncbi.nlm.nih.gov/pubmed/35145060
http://dx.doi.org/10.1038/s41419-022-04580-8

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