The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization

Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of Parkinson’s disease. Although the intensely anionic C-terminal domain (CTD) of αSN does not form part of the amyloid core region or affect membrane binding ability, truncation or reduction of charges in the C...

Descripción completa

Detalles Bibliográficos
Autores principales: Farzadfard, Azad, Pedersen, Jannik Nedergaard, Meisl, Georg, Somavarapu, Arun Kumar, Alam, Parvez, Goksøyr, Louise, Nielsen, Morten Agertoug, Sander, Adam Frederik, Knowles, Tuomas P. J., Pedersen, Jan Skov, Otzen, Daniel Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831632/
https://www.ncbi.nlm.nih.gov/pubmed/35145226
http://dx.doi.org/10.1038/s42003-022-03059-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831632/
https://www.ncbi.nlm.nih.gov/pubmed/35145226
http://dx.doi.org/10.1038/s42003-022-03059-8

Ejemplares similares