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Serotonin 5-HT(2C) receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning

Previous findings have proposed that drugs targeting 5-HT(2C) receptors could be promising candidates in the treatment of trauma- and stress-related disorders. However, the reduction of conditioned freezing observed in 5-HT(2C) receptor knock-out (KO) mice in previous studies could alternatively be...

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Detalles Bibliográficos
Autores principales: Bouchekioua, Youcef, Nebuka, Mao, Sasamori, Hitomi, Nishitani, Naoya, Sugiura, Chiaki, Sato, Masaaki, Yoshioka, Mitsuhiro, Ohmura, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831648/
https://www.ncbi.nlm.nih.gov/pubmed/35145065
http://dx.doi.org/10.1038/s41398-022-01815-2