Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice

Objective: Our study aimed to explore whether gasdermin D (GSDMD)-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Methods: C57BL/6 mice were randomly divided into sham and epilepsy groups. The epilepsy group was intrahippocampally injected with kainic acid to induce...

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Detalles Bibliográficos
Autores principales: Xia, Lu, Liu, Lu, Cai, Yiying, Zhang, Yiying, Tong, Fangchao, Wang, Qiang, Ding, Jing, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831916/
https://www.ncbi.nlm.nih.gov/pubmed/35153737
http://dx.doi.org/10.3389/fphar.2021.751644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831916/
https://www.ncbi.nlm.nih.gov/pubmed/35153737
http://dx.doi.org/10.3389/fphar.2021.751644

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