Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

The microtubule‐associated protein tau gene (MAPT) 10+16 intronic mutation causes frontotemporal lobar degeneration (FTLD) by increasing expression of four‐repeat (4R)‐tau isoforms. We investigated the potential role for astrocytes in the pathogenesis of FTLD by studying the expression of 4R‐tau. We...

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Detalles Bibliográficos
Autores principales: Setó‐Salvia, Núria, Esteras, Noemi, de Silva, Rohan, de Pablo‐Fernandez, Eduardo, Arber, Charles, Toomey, Christina E., Polke, James M., Morris, Huw R., Rohrer, Jonathan D., Abramov, Andrey Y., Patani, Rickie, Wray, Selina, Warner, Thomas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831975/
https://www.ncbi.nlm.nih.gov/pubmed/34951131
http://dx.doi.org/10.1111/jcmm.17136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831975/
https://www.ncbi.nlm.nih.gov/pubmed/34951131
http://dx.doi.org/10.1111/jcmm.17136

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