An Insight on the Pathways Involved in Crizotinib and Sunitinib Induced Hepatotoxicity in HepG2 Cells and Animal Model

Both crizotinib and sunitinib, novel orally-active multikinase inhibitors, exhibit antitumor activity and extend the survival of patients with a malignant tumor. However, some patients may suffer liver injury that can further limit the clinical use of these drugs, however the mechanisms underlying h...

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Detalles Bibliográficos
Autores principales: Guo, Lin, Tang, Tingli, Fang, Dongmei, Gong, Hui, Zhang, Bikui, Zhou, Yueyin, Zhang, Leiyi, Yan, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832280/
https://www.ncbi.nlm.nih.gov/pubmed/35155225
http://dx.doi.org/10.3389/fonc.2022.749954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832280/
https://www.ncbi.nlm.nih.gov/pubmed/35155225
http://dx.doi.org/10.3389/fonc.2022.749954

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