Cargando…

Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle

Neutrophils are predominantly glycolytic cells that derive little ATP from oxidative phosphorylation; however, they possess an extensive mitochondrial network and maintain a mitochondrial membrane potential. Although studies have shown neutrophils need their mitochondria to undergo apoptosis and reg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Willson, Joseph A., Arienti, Simone, Sadiku, Pranvera, Reyes, Leila, Coelho, Patricia, Morrison, Tyler, Rinaldi, Giulia, Dockrell, David H., Whyte, Moira K. B., Walmsley, Sarah R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Phagocytes, Granulocytes, and Myelopoiesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832465/ https://www.ncbi.nlm.nih.gov/pubmed/34411229 http://dx.doi.org/10.1182/blood.2021011010

Ejemplares similares

Phosphorylation of threonine 154 in p40(phox) is an important physiological signal for activation of the neutrophil NADPH oxidase
por: Chessa, Tamara A. M., et al.
Publicado: (2010)

Dasatinib inhibits proinflammatory functions of mature human neutrophils
por: Futosi, Krisztina, et al.
Publicado: (2012)

A NET-thrombosis axis in COVID-19
por: Hidalgo, Andrés
Publicado: (2020)

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
por: Middleton, Elizabeth A., et al.
Publicado: (2020)

A neutrophil activation signature predicts critical illness and mortality in COVID-19
por: Meizlish, Matthew L., et al.
Publicado: (2021)

Resolvin T-series reduce neutrophil extracellular traps
por: Chiang, Nan, et al.
Publicado: (2022)

Impaired formation of neutrophil extracellular traps in patients with MDS
por: Brings, Carolin, et al.
Publicado: (2022)

Clearing NETs with T-series resolvins
por: Filep, János G.
Publicado: (2022)

Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
por: Mahat, Upendra, et al.
Publicado: (2022)

A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis
por: Sohn, Jihee, et al.
Publicado: (2022)

Inflammasome activation in neutrophils of patients with severe COVID-19
por: Aymonnier, Karen, et al.
Publicado: (2022)

Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases
por: Meng, Fanjing, et al.
Publicado: (2022)

Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor
por: Dale, David C., et al.
Publicado: (2022)

Absolute neutrophil count by Duffy status among healthy Black and African American adults
por: Merz, Lauren E., et al.
Publicado: (2022)

Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load
por: Eddins, Devon J., et al.
Publicado: (2022)

IFNγ regulates NAD(+) metabolism to promote the respiratory burst in human monocytes
por: McCann, Katelyn J., et al.
Publicado: (2022)

CD11c regulates neutrophil maturation
por: Hou, Lifei, et al.
Publicado: (2022)

Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice
por: Willis, Alexander J., et al.
Publicado: (2022)

NADPH oxidase 2 limits amplification of IL-1β–G-CSF axis and an immature neutrophil subset in murine lung inflammation
por: Song, Zhimin, et al.
Publicado: (2022)

Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase
por: Sprenkeler, Evelien G. G., et al.
Publicado: (2023)

Secondary bile acids function through the vitamin D receptor in myeloid progenitors to promote myelopoiesis
por: Thompson, Brandon, et al.
Publicado: (2023)

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes
por: Linder, Monika I., et al.
Publicado: (2023)

Tracing the evolutionary history of blood cells to the unicellular ancestor of animals
por: Nagahata, Yosuke, et al.
Publicado: (2022)

Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNγ-dependent iNOS expression in the vasculature of healthy mice
por: Morton, Jonathan, et al.
Publicado: (2008)

Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon
por: Cervantes-Barragan, Luisa, et al.
Publicado: (2007)

Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response
por: Sadiku, Pranvera, et al.
Publicado: (2019)

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
por: Langston, P. Kent, et al.
Publicado: (2019)

Glycerol-3-Phosphate Shuttle Is Involved in Development and Virulence in the Rice Blast Fungus Pyricularia oryzae
por: Shi, Yongkai, et al.
Publicado: (2018)

HIF-mediated innate immune responses: cell signaling and therapeutic implications
por: Harris, Alison J, et al.
Publicado: (2014)

Elderly Hemopoietic and Inflammatory Signature for Life-Threatening COVID-19 Infection
por: Romero, Jesus, et al.
Publicado: (2020)

The Experience of the Cooperation in Science and Technology European Network for Innovative Diagnosis and Treatment of Chronic Neutropenias (COST EuNet-INNOCHRON) Action and the Sweden Experience in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Era
por: Spanoudakis, Michail, et al.
Publicado: (2021)

Neutrophil Metabolic Rewiring in Severe and Mild COVID-19
por: Li, Yafeng, et al.
Publicado: (2021)

Assessment of Macrophage Inflammatory Biomarkers and Neutrophil Extracellular Traps Associated Proteins in COVID-19 Patients
por: Lopez de Frutos, Laura, et al.
Publicado: (2021)

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo
por: Harris, Alison J., et al.
Publicado: (2019)

Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis
por: Sadiku, Pranvera, et al.
Publicado: (2021)

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis
por: Sadiku, Pranvera, et al.
Publicado: (2021)

Conditions Conducive to the Glutathionylation of Complex I Subunit NDUFS1 Augment ROS Production following the Oxidation of Ubiquinone Linked Substrates, Glycerol-3-Phosphate and Proline
por: Wang, Kevin, et al.
Publicado: (2022)

Preparative‐Scale Enzymatic Synthesis of rac‐Glycerol‐1‐phosphate from Crude Glycerol Using Acid Phosphatases and Phosphate
por: Tasnádi, Gábor, et al.
Publicado: (2020)

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
por: Sadiku, Pranvera, et al.
Publicado: (2017)

Methylated metabolite of arsenite blocks glycerol production in yeast by inhibition of glycerol-3-phosphate dehydrogenase
por: Lee, Jongmin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qtjk4ddhuvq5p2kv7dbrmpdofa