Aged healthy mice acquire clonal hematopoiesis mutations

Chin and colleagues used detailed mutational analysis of aged mice and transplantation to evaluate the mouse as a model of clonal hematopoiesis (CH). Their data suggest that while murine hematopoietic stem cells acquire mutations in CH-associated genes when aged and CH clones can expand after transp...

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Autores principales: Chin, Desmond Wai Loon, Yoshizato, Tetsuichi, Virding Culleton, Stina, Grasso, Francesca, Barbachowska, Magdalena, Ogawa, Seishi, Jacobsen, Sten Eirik W., Woll, Petter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Letter to Blood
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832470/
https://www.ncbi.nlm.nih.gov/pubmed/34665864
http://dx.doi.org/10.1182/blood.2021014235
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author Chin, Desmond Wai Loon
Yoshizato, Tetsuichi
Virding Culleton, Stina
Grasso, Francesca
Barbachowska, Magdalena
Ogawa, Seishi
Jacobsen, Sten Eirik W.
Woll, Petter S.
author_facet Chin, Desmond Wai Loon
Yoshizato, Tetsuichi
Virding Culleton, Stina
Grasso, Francesca
Barbachowska, Magdalena
Ogawa, Seishi
Jacobsen, Sten Eirik W.
Woll, Petter S.
author_sort Chin, Desmond Wai Loon
collection PubMed
description Chin and colleagues used detailed mutational analysis of aged mice and transplantation to evaluate the mouse as a model of clonal hematopoiesis (CH). Their data suggest that while murine hematopoietic stem cells acquire mutations in CH-associated genes when aged and CH clones can expand after transplantation (as in humans), these are rare events. Nevertheless, genetically manipulated murine models mimicking human CH are feasible and may prove useful in the future.
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spelling pubmed-88324702022-03-02 Aged healthy mice acquire clonal hematopoiesis mutations Chin, Desmond Wai Loon Yoshizato, Tetsuichi Virding Culleton, Stina Grasso, Francesca Barbachowska, Magdalena Ogawa, Seishi Jacobsen, Sten Eirik W. Woll, Petter S. Blood Letter to Blood Chin and colleagues used detailed mutational analysis of aged mice and transplantation to evaluate the mouse as a model of clonal hematopoiesis (CH). Their data suggest that while murine hematopoietic stem cells acquire mutations in CH-associated genes when aged and CH clones can expand after transplantation (as in humans), these are rare events. Nevertheless, genetically manipulated murine models mimicking human CH are feasible and may prove useful in the future. American Society of Hematology 2022-01-27 /pmc/articles/PMC8832470/ /pubmed/34665864 http://dx.doi.org/10.1182/blood.2021014235 Text en © 2022 by The American Society of Hematology This article is made available via the PMC Open Access Subset for unrestricted reuse and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Letter to Blood
Chin, Desmond Wai Loon
Yoshizato, Tetsuichi
Virding Culleton, Stina
Grasso, Francesca
Barbachowska, Magdalena
Ogawa, Seishi
Jacobsen, Sten Eirik W.
Woll, Petter S.
Aged healthy mice acquire clonal hematopoiesis mutations
title Aged healthy mice acquire clonal hematopoiesis mutations
title_full Aged healthy mice acquire clonal hematopoiesis mutations
title_fullStr Aged healthy mice acquire clonal hematopoiesis mutations
title_full_unstemmed Aged healthy mice acquire clonal hematopoiesis mutations
title_short Aged healthy mice acquire clonal hematopoiesis mutations
title_sort aged healthy mice acquire clonal hematopoiesis mutations
topic Letter to Blood
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832470/
https://www.ncbi.nlm.nih.gov/pubmed/34665864
http://dx.doi.org/10.1182/blood.2021014235
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