The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML

Translocations involving the NUP98 gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular dependency in NUP98-fusion leukemia, and therefore we investigated the efficacy of therapeutic blockade of the menin-MLL1 interaction in...

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Detalles Bibliográficos
Autores principales: Heikamp, Emily B., Henrich, Jill A., Perner, Florian, Wong, Eric M., Hatton, Charles, Wen, Yanhe, Barwe, Sonali P., Gopalakrishnapillai, Anilkumar, Xu, Haiming, Uckelmann, Hannah J., Takao, Sumiko, Kazansky, Yaniv, Pikman, Yana, McGeehan, Gerard M., Kolb, Edward A., Kentsis, Alex, Armstrong, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832476/
https://www.ncbi.nlm.nih.gov/pubmed/34582559
http://dx.doi.org/10.1182/blood.2021012806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832476/
https://www.ncbi.nlm.nih.gov/pubmed/34582559
http://dx.doi.org/10.1182/blood.2021012806

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