Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer

Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in select immunotherapy regimens shows early promise. Though the TGFβ target SMAD4 is deleted in approximately 55% of PDAC tumors, the effects of SM...

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Detalles Bibliográficos
Autores principales: Principe, Daniel R., Underwood, Patrick W., Kumar, Sandeep, Timbers, Kaytlin E., Koch, Regina M., Trevino, Jose G., Munshi, Hidayatullah G., Rana, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832494/
https://www.ncbi.nlm.nih.gov/pubmed/35155243
http://dx.doi.org/10.3389/fonc.2022.806963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832494/
https://www.ncbi.nlm.nih.gov/pubmed/35155243
http://dx.doi.org/10.3389/fonc.2022.806963

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