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Ryanodine receptor RyR1-mediated elevation of Ca(2+) concentration is required for the late stage of myogenic differentiation and fusion
BACKGROUND: Cytosolic Ca(2+) plays vital roles in myogenesis and muscle development. As a major Ca(2+) release channel of endoplasmic reticulum (ER), ryanodine receptor 1 (RyR1) key mutations are main causes of severe congenital myopathies. The role of RyR1 in myogenic differentiation has attracted...
Autores principales: | Qiu, Kai, Wang, Yubo, Xu, Doudou, He, Linjuan, Zhang, Xin, Yan, Enfa, Wang, Lu, Yin, Jingdong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832842/ https://www.ncbi.nlm.nih.gov/pubmed/35144690 http://dx.doi.org/10.1186/s40104-021-00668-x |
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