Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development

Oncogenic imbalance of DNA methylation is well recognized in cancer development. The ten-eleven translocation (TET) family of dioxygenases, which facilitates DNA demethylation, is frequently dysregulated in cancers. How such dysregulation contributes to tumorigenesis remains poorly understood, espec...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Qin, Wang, Chao, Zhou, Jia-Xin, Xu, Zhi-Mei, Gao, Juan, Sui, Pengfei, Walsh, Colum P., Ji, Hongbin, Xu, Guo-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832965/
https://www.ncbi.nlm.nih.gov/pubmed/35110400
http://dx.doi.org/10.1073/pnas.2107599119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832965/
https://www.ncbi.nlm.nih.gov/pubmed/35110400
http://dx.doi.org/10.1073/pnas.2107599119

Ejemplares similares