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Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development

Oncogenic imbalance of DNA methylation is well recognized in cancer development. The ten-eleven translocation (TET) family of dioxygenases, which facilitates DNA demethylation, is frequently dysregulated in cancers. How such dysregulation contributes to tumorigenesis remains poorly understood, espec...

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Detalles Bibliográficos
Autores principales:	Xu, Qin, Wang, Chao, Zhou, Jia-Xin, Xu, Zhi-Mei, Gao, Juan, Sui, Pengfei, Walsh, Colum P., Ji, Hongbin, Xu, Guo-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832965/ https://www.ncbi.nlm.nih.gov/pubmed/35110400 http://dx.doi.org/10.1073/pnas.2107599119

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