BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer

BRD4 is well known for its role in super-enhancer organization and transcription activation of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are being pursued as promising therapeutics for cancer treatment. However, drug resistance also occurs for BRD4-targeted thera...

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Detalles Bibliográficos
Autores principales: Liu, Beibei, Liu, Xinhua, Han, Lulu, Chen, Xing, Wu, Xiaodi, Wu, Jiajing, Yan, Dong, Wang, Yue, Liu, Shumeng, Shan, Lin, Zhang, Yu, Shang, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832982/
https://www.ncbi.nlm.nih.gov/pubmed/35105803
http://dx.doi.org/10.1073/pnas.2109133119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832982/
https://www.ncbi.nlm.nih.gov/pubmed/35105803
http://dx.doi.org/10.1073/pnas.2109133119

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