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BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer
BRD4 is well known for its role in super-enhancer organization and transcription activation of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are being pursued as promising therapeutics for cancer treatment. However, drug resistance also occurs for BRD4-targeted thera...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832982/ https://www.ncbi.nlm.nih.gov/pubmed/35105803 http://dx.doi.org/10.1073/pnas.2109133119 |