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MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function

Multidrug Resistance Proteins (MRPs) are transporters that play critical roles in cancer even though the physiological substrates of these enigmatic transporters are poorly elucidated. In Caenorhabditis elegans, MRP5/ABCC5 is an essential heme exporter because mrp-5 mutants are unviable due to their...

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Detalles Bibliográficos
Autores principales: Chambers, Ian G., Kumar, Praveen, Lichtenberg, Jens, Wang, Pengcheng, Yu, Jianshi, Phillips, John D., Kane, Maureen A., Bodine, David, Hamza, Iqbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832985/
https://www.ncbi.nlm.nih.gov/pubmed/35121660
http://dx.doi.org/10.1073/pnas.2111617119