Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation

Activation of the GTPase Rab7/Ypt7 by its cognate guanine nucleotide exchange factor (GEF) Mon1-Ccz1 marks organelles such as endosomes and autophagosomes for fusion with lysosomes/vacuoles and degradation of their content. Here, we present a high-resolution cryogenic electron microscopy structure o...

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Detalles Bibliográficos
Autores principales: Klink, Björn U., Herrmann, Eric, Antoni, Claudia, Langemeyer, Lars, Kiontke, Stephan, Gatsogiannis, Christos, Ungermann, Christian, Raunser, Stefan, Kümmel, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833172/
https://www.ncbi.nlm.nih.gov/pubmed/35105815
http://dx.doi.org/10.1073/pnas.2121494119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833172/
https://www.ncbi.nlm.nih.gov/pubmed/35105815
http://dx.doi.org/10.1073/pnas.2121494119

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